venofer dosing calculatorshallow wicker basket
May increase risk of hypotension. Jacobs P, Dommisse J. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Applies only to oral form of both agents. Share cases and questions with Physicians on Medscape consult. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Applies only to oral form of both agents. This drug is available at the lowest co-pay. Parenteral iron supplementation. The recipient will receive more details and instructions to access this offer. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Administer on 5 different occasions over a 14 day period. Applies only to oral form of both agents. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Human studies not conducted. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Avoid or Use Alternate Drug. Either decreases levels of the other by inhibition of GI absorption. Use Caution/Monitor. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Manage and view all your plans together even plans in different states. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Found in multiple references. Contraindicated. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. This drug is available at a higher level co-pay. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Uses for Iron Sucrose Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Applies only to oral form of both agents. Medicinal forms iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Nutr Clin Pract. Schweiz Med Wochenschr; 100(7):301-3. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Most FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Iron sucrose: 20 mg/mL. Available for Android and iOS devices. Use Caution/Monitor. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. A healthcare provider will give you this injection. Separate by at least 4 hours. 1970;100(7):301303. These can be input in g/dL, g/L or mmol/L. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Keep all medical and lab appointments. Applies only to oral form of both agents. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Applies only to oral form of both agents. 1) Ganzoni AM. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. commonly, these are generic drugs. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in View the formulary and any restrictions for each plan. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Separate dosing of tetracyclines from these products. Canada residents can call a provincial poison control center. In the text below the tool there is more information on how the iron deficit is calculated. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Before using, check this product visually for particles or discoloration. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Mean change in Hgb from baseline to Week 5 2,5 Use Caution/Monitor. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Venofer treatment may be repeated if necessary. Applies only to oral form of both agents. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Use Caution/Monitor. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Med J Aust; 193(9):525-32. Intravenous iron sucrose: establishing a safe dose. Applies only to oral form of both agents. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Accessed: 4/12/2011. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. FERAHEME met the predefined criteria for non-inferiority to Venofer . 1996 Aug;11(4):139-46. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. ANNA J. commonly, these are "non-preferred" brand drugs. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Either increases effects of the other by pharmacodynamic synergism. informational and educational purposes only. Learn how to store and discard medical supplies safely. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Use Caution/Monitor. If you log out, you will be required to enter your username and password the next time you visit. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Applies only to oral form of both agents. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Each mL contains 20 mg of elemental iron. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Venofer has not been studied in patients younger than 2 years old. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Use Caution/Monitor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Monitor for signs and symptoms of hypotension following each administration of Venofer. Use Caution/Monitor. Minor (1)iron sucrose, benazepril. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. 1995 Mar-Apr;11(2):163-8. Use Caution/Monitor. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Drug class: Iron products. Applies only to oral form of both agents. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Treatment of anemia due to iron deficiency. Minor (1)iron sucrose, captopril. Avoid or Use Alternate Drug. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Anemia caused by the depletion of iron is called iron deficiency anemia. Do Not Copy, Distribute or otherwise Disseminate without express permission. Applies only to oral form of both agents. Although the original formula requires the weight in kilograms, values input in lbs are transformed. J Med. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Discuss the risks and benefits with your doctor.This medication passes into breast milk. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Included in the iron dextran package insert. If we don't have the calculator you need we'll try to make it for you and add it to the website. Applies only to oral form of both agents. UpToDate. Do not administer Venofer to patients with iron overload. Applies only to oral form of both agents. Use Caution/Monitor. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Applies only to oral form of both agents. Applies only to oral form of both agents. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. This site complies with the HONcode standard for trust- worthy health information: verify here. This calculator will help pinpoint potential causes of anemia based on Use Caution/Monitor. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. J Lab Clin Med; 111(5):566-70. Applies only to oral form of both agents. Pregnancy: Risk Summary-Clinical Considerations. Most Minor/Significance Unknown. Applies only to oral form of both agents. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. 2015: 763576. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Test Dose: Not required. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Am J Hosp Pharm. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Avoid or Use Alternate Drug. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Applies only to oral form of both agents. Ganzoni AM. Avoid or Use Alternate Drug. Feraheme does not contain antimicrobial preservatives. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Parenteral iron dextran therapy: a review. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Applies only to oral form of both agents. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). *Administer early during the dialysis session. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. 2. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Applies only to oral form of both agents. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Minor/Significance Unknown. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. ]Venofer treatment may be repeated if iron deficiency reoccurs. Corrected Calcium. Use alternatives if available. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. J Lab Clin Med. Applies only to oral form of both agents. Total dose iron infusion: safety and efficacy in predialysis patients. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL
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