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Calabrese, V., Cornelius, C., Stella, A. M., and Calabrese, E. J. Rejuvenation.Res. View abstract. 1988;192(4):155-157. Herrmann, W. M., Dietrich, B., and Hiersemenzel, R. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. What time of day is best to take L-carnitine? [Updated!] Insomnia, headaches and vertigo are common side effects. BJU Int 2001;88:63-7.. View abstract. View abstract. Brevetti, G., di Lisa, F., Perna, S., Menabo, R., Barbato, R., Martone, V. D., and Siliprandi, N. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. View abstract. 2009;10(2):103-110. Fortin, G., Yurchenko, K., Collette, C., Rubio, M., Villani, A. C., Bitton, A., Sarfati, M., and Franchimont, D. L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. Hirose S, Mitsudome A, Yasumoto S, et al. Am J Clin Nutr 1990;52(5):889-894. Caponnetto S, Canale C, Masperone MA, et al. BMC Cardiovasc Disord. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. J Inherit.Metab Dis 2008;31(3):361-367. L-Carnitine - A Review of Benefits, Side Effects and Dosage - Healthline Acetyl-L-Carnitine - WebMD View abstract. View abstract. Cardiovasc Drugs Ther 1995;9:749-53. View abstract. 1986;13(6):268-276. Xu XQ, Jing ZC, Jiang X, et al. Tell your doctor if you are pregnant or plan to become pregnant. View abstract. 2007;135(11):1446-1449. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. View abstract. Inflammation contributes to many medical conditions, including . View abstract. Brevetti G, Perna S, Sabba C, et al. Biochem Pharmacol 1995;49:1403-10. Kumar, R., Gautam, G., and Gupta, N. P. Drug therapy for idiopathic male infertility: rationale versus evidence. This review describes the mechanism of action, metabolism and pharmacokinetics of l-carnitine. It can have serious effects, leading to excessive daytime sleepiness, a higher risk of auto accidents, and widespread health effects from sleep deprivation. J Formos.Med.Assoc. Fagher, B., Thysell, H., Nilsson-Ehle, P., Monti, M., Olsson, L., Eriksson, M., Lindstedt, S., and Lindholm, T. The effect of D,L-carnitine supplementation on muscle metabolism, neuropathy, cardiac and hepatic function in hemodialysis patients. Youle, M. Acetyl-L-carnitine in HIV-associated antiretroviral toxic neuropathy. Nutr Res 1997;17:405-414. J Nephrol. View abstract. 8588 Background: Carnitine is a natural aminoacid derivative that plays a crucial role in cellular energy metabolism. View abstract. Ann Neurol 1994;36:680-1. Ren Fail. Clin Lymphoma Myeloma Leuk. View abstract. View abstract. Demeyere, R., Lormans, P., Weidler, B., Minten, J., Van Aken, H., and Flameng, W. Cardioprotective effects of carnitine in extensive aortocoronary bypass grafting: a double-blind, randomized, placebo-controlled clinical trial. Goldenberg, N. A., Krantz, M. J., and Hiatt, W. R. L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. Gomez-Amores, L., Mate, A., Miguel-Carrasco, J. L., Jimenez, L., Jos, A., Camean, A. M., Revilla, E., Santa-Maria, C., and Vazquez, C. M. L-carnitine attenuates oxidative stress in hypertensive rats. L-carnitine supplementation improves fatigue, mood and sleep in cancer Clin Ter 3-31-1990;132(6 Suppl):479-510. 2007;45(7):513-517. Res Pharm Sci. Int J Fertil 1977;22:85-91. View abstract. Generic name: levocarnitine (oral) [LEE-voe-KAR-ni-teen] J Nutr Sci Vitaminol. Copyright 1996-2023 Cerner Multum, Inc. Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. 2011;17(6):I15-I23. Carnitine - Health Professional Fact Sheet - National Institutes of Health Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression. As with any supplement, you should speak with your doctor before taking L-carnitine. Specific populations may benefit from L-carnitine supplements. Monaldi Arch.Chest Dis 2007;68(2):110-114. View abstract. View abstract. This article explains why some people have a fast metabolism and how you can speed up yours to burn more calories. The protective effect of carnitine in human diphtheric myocarditis. View abstract. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. 2014 Jul 21;14:88. Clinical and biochemical effects. Madeddu, C., Dessi, M., Panzone, F., Serpe, R., Antoni, G., Cau, M. C., Montaldo, L., Mela, Q., Mura, M., Astara, G., Tanca, F. M., Maccio, A., and Mantovani, G. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. View abstract. Clin Ter. 2011;22(6):1155-1159. Georgala S, Schulpis KH, Georgala C, Michas T. L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. Nephrol.Dial Transplant 2008;23(3):991-997. View abstract. Vicari E, La Vignera S, Calogero AE. Report of one case]. View abstract. 2012;4:CD006282. Mantovani, G. Randomised phase III clinical trial of 5 different arms of treatment on 332 patients with cancer cachexia. Yderstraede, K. B., Pedersen, F. B., Dragsholt, C., Trostmann, A., Laier, E., and Larsen, H. F. The effect of L-carnitine on lipid metabolism in patients on chronic haemodialysis. Jing, L., Li, W. M., Zhou, L. J., and Song, J. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Are There Side Effects to L-Carnitine Supplementation? Neurobiol Aging 1995;16:1-4. Nutrients 2018;10(2). Sunamori M, Nakagawa T, Fujisawa S, and et al. View abstract. Efficacy of L-carnitine and propranolol in the management of acute theophylline toxicity. JPEN J Parenter.Enteral Nutr 1988;12(1):29-34. 1990;71(5):520-528. Bonavita E, Bertuzzi D, Bonavita J, and et al. Am.J Cardiol. View abstract. 11 Ways to Overcome Hashimoto's Fatigue - Dr. Izabella Wentz Eur J Urol 1996;30(Suppl 2):954. Lenzi, A., Lombardo, F., Sgro, P., Salacone, P., Caponecchia, L., Dondero, F., and Gandini, L. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. View abstract. Clin Rheumatol. Effects of parenteral L-carnitine supplementation on fat metabolism and nutrition in premature neonates. Calandrella, N., De, Seta C., Scarsella, G., and Risuleo, G. Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma. 9 Acetyl-L-Carnitine Benefits + Dosage & Side Effects - SelfHacked 2007;44(2):83-90. View abstract. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis. The process is the ability to heal the body, which is a daily process. Berthillier G, Eichenberger D, Carrier HN, et al. This may lead to irritability, hyperactivity or insomnia. J Cardiol 1991;21(2):493-504. J Child Neurol 2003;18:552-4. Neurological: headaches, dizziness. A long-term, randomised, double-blind, placebo-controlled study. J Am Soc Nephrol 2002;13:708-14.. View abstract. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. Morgante, G., Scolaro, V., Tosti, C., Di, Sabatino A., Piomboni, P., and De, Leo, V. [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. NAC: The Amino Acid That Turns Psychiatry on Its Head Eur J Clin Pharmacol 1988;35(5):555-562. View abstract. View abstract. Malaguarnera, M., Pistone, G., Elvira, R., Leotta, C., Scarpello, L., and Liborio, R. Effects of L-carnitine in patients with hepatic encephalopathy. View abstract. Problems with Acetyl L-Carnitine? - Phoenix Rising ME/CFS Forums Benton, D. and Donohoe, R. T. The influence on cognition of the interactions between lecithin, carnitine and carbohydrate. A double-blind randomized study. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. J Inherit.Metab Dis 2009;32(4):488-497. Chen, J. C., Tsai, T. C., Liu, C. S., and Lu, C. T. Acute hearing loss in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Maccio, A., Madeddu, C., Gramignano, G., Mulas, C., Floris, C., Sanna, E., Cau, M. C., Panzone, F., and Mantovani, G. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life. Malvagia, S., Papi, L., Morrone, A., Donati, M. A., Ciani, F., Pasquini, E., la, Marca G., Scholte, H. R., Genuardi, M., and Zammarchi, E. Fatal malonyl CoA decarboxylase deficiency due to maternal uniparental isodisomy of the telomeric end of chromosome 16. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. For this reason, L-carnitine levels are often lower in vegetarians and vegans, since they restrict or avoid animal products (6, 62). View abstract. View abstract. View abstract. Am.J Gastroenterol. Holzhauer, P. Casuistry: medical nutrition intervention with specific micronutrient and exercise therapy in pancreatic cancer. Immunopharmacol.Immunotoxicol. Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children. Neuromuscul.Disord. Although the cause of depression is unclear, scientists have hypothesized that depression may be partly caused by the overactivation of the HPA axis - the part of the nervous system that responds to stress. 2014 Feb;99(2):408-22. Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., and Shea, T. B. View abstract. Pryor, J. L., Glass, S. L., Campagnone, J., and Sigman, M. Randomized double blind placebo controlled trial of carnitine for the treatment of idiopathic asthenospermia. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). Am.J Med Genet. View abstract. Background and aim: Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. View abstract. Raskind JY, El-Chaar GM. Sangouni AA, Pakravanfar F, Ghadiri-Anari A, Nadjarzadeh A, Fallahzadeh H, Hosseinzadeh M. The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial. Taking too much (2 to 3 grams . Whats more, five of the participants taking L-carnitine experienced nausea or diarrhea (24). Effects of L-carnitine on leukocyte function and viability in hemodialysis patients: A double-blind randomized trial. View abstract. Iranian J.Nutr.Sci.Food Technol. Ann N Y Acad Sci 2004;1033:30-41. Nagai, N., Kameda, N., Kobashi, R., Nishida, M., Horikawa, C., Egawa, K., Yoshimura, M., Kitagawa, Y., Abe, K., Kiso, Y., Sakane, N., Kotani, K., and Moritani, T. Effect of L-carnitine intake upon reduction of hunger feeling in young healthy females. Pediatr.Res 1982;16(2):89-91. Arch.Pharm Res 2012;35(11):1945-1952. Effect of L-carnitine on the physical fitness of thalassemic patients. Lipotropic Injections Benefits, Side Effects, Dosage, and Cost - Healthline Rajasekar, P., Palanisamy, N., and Anuradha, C. V. Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat. Check with your doctor as soon as possible if any of the following side effects occur while taking levocarnitine: Some side effects of levocarnitine may occur that usually do not need medical attention. L-Carnitine should be taken at evenly spaced intervals every 3 or 4 hours. Online ahead of print. Benefits of L-carnitine. Paediatr Drugs. List of All Orphan Products Designations and Approvals. 2011;18(1):18-22. Ellaway, C. J., Peat, J., Williams, K., Leonard, H., and Christodoulou, J. Medium-term open label trial of L-carnitine in Rett syndrome. Healthline Media does not provide medical advice, diagnosis, or treatment. L-arginine should be used with caution. World J Gastroenterol. There are few negative side effects from this supplement at reasonable doses. Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. Propionyl-L-Carnitine - RxList 2000;2(2):189-193. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. L-carnitine: a way to decrease cellular toxicity of ifosfamide? L-Carnitine is used to treat carnitine deficiency. View abstract. Physiologie. Dementia 1991;2(6):333-337. View abstract. Cruciani RA, Dvorkin E, Homel P, et al. Although the recommended dose varies, around 5002,000 mg (0.52 grams) seems to be both safe and effective. Acta Diabetol. Sproule, D. M., Dyme, J., Coku, J., de, Vinck D., Rosenzweig, E., Chung, W. K., and De Vivo, D. C. Pulmonary artery hypertension in a child with MELAS due to a point mutation of the mitochondrial tRNA((Leu)) gene (m.3243A > G). Feillet, F., Ogier, H., Cheillan, D., Aquaviva, C., Labarthe, F., Baruteau, J., Chabrol, B., de, Lonlay P., Valayanopoulos, V., Garnotel, R., Dobbelaere, D., Briand, G., Jeannesson, E., Vassault, A., and Vianey-Saban, C. [Medium-chain acyl-CoA-dehydrogenase (MCAD) deficiency: French consensus for neonatal screening, diagnosis, and management]. These side effects may go away during treatment as your body adjusts to the medicine. Karimi, M., Mohammadi, F., Behmanesh, F., Samani, S. M., Borzouee, M., Amoozgar, H., and Haghpanah, S. Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia. Suchitra, M. M., Ashalatha, V. L., Sailaja, E., Rao, A. M., Reddy, V. S., Bitla, A. R., Sivakumar, V., and Rao, P. V. The effect of L-carnitine supplementation on lipid parameters, inflammatory and nutritional markers in maintenance hemodialysis patients. View abstract. Dig.Dis. View abstract. Brain Dev. View abstract. Diabetologia 1997;40(1):A32. Torrioli, M. G., Vernacotola, S., Peruzzi, L., Tabolacci, E., Mila, M., Militerni, R., Musumeci, S., Ramos, F. J., Frontera, M., Sorge, G., Marzullo, E., Romeo, G., Vallee, L., Veneselli, E., Cocchi, E., Garbarino, E., Moscato, U., Chiurazzi, P., D'Iddio, S., Calvani, M., and Neri, G. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Katiyar, A. and Aaron, C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. In one study, 2 grams of acetyl-L-carnitine per day resulted in an almost 10-point drop in systolic blood pressure the top number of a blood pressure reading and an important indicator of heart health and disease risk (23). 2010;14(4):498-504. Eur Heart J 1994;15:1267-73. [Ref], Very common (10% or more): Anemia (12%)[Ref], Common (1% to 10%): Kidney failure (chronic hemodialysis patients)[Ref], Common (1% to 10%): Parathyroid disorder[Ref], Very common (10% or more): Pharyngitis (27%), cough increase (18%), dyspnea (11%), rhinitis (11%), Common (1% to 10%): Bronchitis, sinusitis[Ref], Common (1% to 10%): Amblyopia, eye disorder[Ref], Common (1% to 10%): Urinary tract infection[Ref], Very common (10% or more): Hypertension (21%), hypotension (19%), Common (1% to 10%): Atrial fibrillation, arrhythmia, cardiovascular disorder, electrocardiogram abnormal, palpitations, tachycardia, vascular disorder[Ref], Common (1% to 10%): Allergic reaction[Ref], Common (1% to 10%): Depression, anxiety, drug dependence, insomnia[Ref], Very common (10% or more): Infection (24%)[Ref]. Study carried out in septic patients of an intensive care unit. View abstract. Dig Liver Dis 2007;39:922-8. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. In a 90-day study, people with alcohol addictions who took 2 grams of acetyl-L-carnitine per day experienced significant improvements in all measures of brain function (38). Cancer Biol.Ther 7-15-2011;12(2):125-130. View abstract. 1989;4(5):366-371. Bradycardia Causes + 9 Natural Ways to Improve Slow Heart Rate 2002;2(3):240-243. View abstract. Eur.J Cancer 7-19-2005; View abstract. Gut. Coto V, D'Alessandro L, Grattarola G, and et al. Int.J Cancer 9-15-2008;123(6):1227-1239. 2008;42(11):1686-1691. Toxicol Res (Camb). Sweets, treats, and desserts are high in added sugars and saturated fats. View abstract. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients. Plasma carnitine deficiency: Clinical observations in 51 pediatric patients. Curr Ther res, Clin exp 1982;32(11):116-127. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. View abstract. L-Carnitine L-Tartrate (LCLT) is typically used for physical performance and power output. Acta Anaesthesiol.Scand. Int Urol Nephrol 2021;53(10):2149-2158. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. View abstract. 2-8-2006;107(1):54-60. View abstract. 2010;33(2):132-136. Mult Scler 2006;12:321-4. 2010;28(2):127-132. New study links L-carnitine in red meat to heart disease [Ref], There have been reports from clinical trials of significant increases in platelet aggregation associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to hemodialysis patients. 1-1-2010;84(1):52-58. 2010;21(3):454-459. View abstract. 2011;6(1):23-32. 2018 Jun;20(3):285-290. Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z. Carnitine supplementation for inborn errors of metabolism. A few people may notice mild headaches. J Inherit.Metab Dis 2006;29(2-3):288-298. View abstract. Benedini, S., Perseghin, G., Terruzzi, I., Scifo, P., Invernizzi, P. L., Del, Maschio A., Lazzarin, A., and Luzi, L. Effect of L-acetylcarnitine on body composition in HIV-related lipodystrophy. Multiple studies have shown that when used, L-carnitine can help reduce the high blood pressure, which along with oxidative stress, serves as one of the main risk factors for heart disease, thus reducing the risk of this horrifying disease and improving the patients' heart health. View abstract. Int J Sport Nutr Exerc.Metab 2000;10(2):199-207. Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. 1987;1(4):238-241. View abstract. Sabry, A. However, this does not explain why insomnia actually occurs. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Changes in lipid pattern. View abstract. Rizos I. Optom.Vis.Sci 2011;88(12):1439-1444. Pacheco, A., Torres, R., Sanhueza, M. E., Elgueta, L., Segovia, E., and Cano, M. [Study of aerobic capacity in chronic hemodialized patients: effect of L-carnitine supplementation]. Drugs Aging 2003;20:761-7. Do not mix citicoline with levodopa, a medication used to treat Parkinson's disease, without talking to your doctor. Even though the chance of adverse side effects is slight, there are two things that we suggest when taking Coenzyme Q10. Pehlivanoglu S, Enar R Mutlu H Sert A Ersalni M Yazicioglu N. The effect of L-carnitine on left ventricular function in patients with acute myocardial infarction treated with streptokinase. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Acetyl-L-carnitine (ALC) is a form of amino-acid carnitine, used as a dietary supplement and nootropic. Indian J Clin Biochem 1992;7:19-21. L-Carnitine supplementation in older women. L-carnitine is an amino acid that is naturally produced in the body. Sports Med 1996;22:109-32. Analysis of the full dataset has . L-carnitine supplementation of a soybean-based formula in early infancy: plasma and urine levels of carnitine and acylcarnitines. Br J Dermatol 1987;117:203-6. Therefore, vegetarians and vegans may want to consider L-carnitine supplements. Examples: atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal), sotalol (Betapace), timolol (Timoptic) and some other drugs whose chemical names end with "-olol." How they can cause insomnia: Beta-blockers have long been associated with sleep disturbances, including awakenings at night and nightmares. View abstract. View abstract. Common L-carnitine side effects include stomach pain, nausea, vomiting and diarrhea. PLoS.One. 2009;32(1):35-40. View abstract. View abstract. View abstract. 2009;19(73):43-50. 1) is a naturally occurring amino acid found in high concentrations in muscle, heart and brain tissues. Am J Cardiol 1997;79:777-80. De Vivo DC, Bohan TP, Coulter DL, et al. View abstract. Clin Exp.Hypertens. All rights reserved. Serjeant, B. E., Harris, J., Thomas, P., and Serjeant, G. R. Propionyl-L-carnitine in chronic leg ulcers of homozygous sickle cell disease: a pilot study.

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